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EC number: 604-580-1 | CAS number: 147256-33-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment carried out according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the long-term toxicity to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
There is no long-term test on aquatic invertebrates available for Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane (CAS No. 147256-33-5).
According to column 2 of Regulation (EC) No 1907/2006, Annex IX, long-term toxicity testing shall only be proposed if the chemical safety assessment indicates the need to investigate further the effects on aquatic organisms. Since the substance is readily biodegradable, chronic exposure of aquatic organisms is unlikely. Furthermore, the substance is not toxic to aquatic organisms up to the limit of water solubility in acute tests (< 0.05 mg/L). In addition, available data indicate, that the test substance is not bioaccumulative. Based on the available information, long-term toxicity to aquatic invertebrates is not expected to be of concern.
Intrinsic properties and fate
Fatty acids, C18-unsatd., mixed with oleic acid and trimethylolpropane is readily biodegradable (70-85% O2 consumption in 28 days; Böner, 2000a, b). According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2012). Therefore, after passing through conventional STPs, only low concentrations of these substances are likely to be (if at all) released into the environment.
Furthermore, the substance exhibits a log Koc value of > 5 and is poorly water soluble (< 0.05 mg/L). The Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2012) states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms. Nevertheless, once this contact takes place, these substances are expected to be removed from the water column to a significant degree by adsorption to sewage sludge (Guidance on information requirements and chemical safety assessment, Chapter R.7a, (ECHA, 2012)) and the rest will be extensively biodegraded (due to ready biodegradability). Thus, discharged concentrations of these substances into the aqueous compartment are likely to be negligible.
Considering this one can assume that the availability of Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane in the aquatic environment is generally very low, which reduces the probability of chronic exposure of aquatic organisms.
Aquatic ecotoxicity data
Available acute aquatic toxicity tests of the substance to fish, invertebrates, algae showed no adverse effects in the range of the water solubility of the substance (< 0.05 mg/L). Furthermore, long-term data for algae show no chronic effects in the range of the water solubility. The obtained results indicate that Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane is likely to show no chronic toxicity to aquatic organisms as well.
Bioaccumulation/Metabolism
Bioaccumulation in aquatic invertebrates is not expected for Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane. Based on the molecular weight (625 - 1762 g/mol), size and structural complexity of the substances, which reduces significantly the absorption due to steric hindrance to cross biological membranes, uptake from medium into auqatic organisms is considered to be low (e.g. Dimitrov et al., 2002).
The supporting BCF/BAF values estimated with the BCFBAF v3.01 program, Arnot-Gobas model including biotransformation (BCF and BAF values of 0.89 L/kg and 0.89-10.92 L/kg, respectively), also indicate that this substance will not be bioaccumulative (all well below 2000).
Conclusion
Due to its ready biodegradability it is not likely that aquatic organisms will be exposed to Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane, since it will be ultimately degraded in sewage treatment plants. Thus, based on the above mentioned results, it is unlikely that the substance will exhibit chronic toxicity to aquatic invertebrates up to the limit of water solubility. Hence, based on the information discussed, no further long-term test with aquatic invertebrates is proposed.
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