Registration Dossier
Registration Dossier
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EC number: 604-580-1 | CAS number: 147256-33-5
Endpoint summary
Administrative data
Description of key information
Additional information
Acute tests evaluating the toxicity of Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane (CAS No. 147256-33-5) to aquatic organisms from three different trophic levels are available. For all three trophic levels (fish, aquatic invertebrates and algae) no toxicity within the range of water solubility was observed.
Long-term tests evaluating the toxicity of Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane to aquatic organisms are only available for algae. The results of this test show no chronic effects within the range of water solubility.
Based on the poor water solubility, no effects up to the limit of water solubility in acute tests, low exposure concentrations in water based on readily biodegradability and the high molecular weight (625-1763 g/mol) which reduces significantly the absorption due to steric hindrance to cross biological membranes, long-term effects in fish and aquatic invertebrates are unlikely to occur.Therefore, the Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need for long-term testing with fish and aquatic invertebrates.
Reliable studies on the toxicity to microorganisms for Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane (CAS No. 147256-33-5) are not available.In accordance with Annex VIII, column 2 (9.1.4) of Regulation (EC) No. 1907/2006, activated sludge respiration inhibition testing is not required since the substance is highly insoluble in water
Additionally, for Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane is readily biodegradable, which indicates that the substances will not cumulate in the environment. Based on these mitigating factors, it is unlikely that microbial toxicity occurs. This assumption is confirmed by a study conducted for the test substance, which is not sufficient to cover this endpoint as the test last only 30 min (Guhl, 1991). In this growth inhibition test with Pseudomonas putida no inhibition was observed up to a test concentration of 10 g/L.
General conclusion
No effects on aquatic organisms were observed in the available studies for Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane in any of the three trophic levels (fish, daphnia, algae) up to the limit of water solubility, neither in the short-term toxicity tests nor in long-term tests with algae. Furthermore, since the substance is readily biodegradable toxic effects on microorganisms is not expected.
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