Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 906-256-8 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- cited in Ballantyne and Snellings: Toxicology Update: Triethylene glycol.
- Author:
- Biodynamics
- Year:
- 1 990
- Bibliographic source:
- J. Appl. Toxicol. 27, 291-299
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Concentration / amount:
- undiluted
Challengeopen allclose all
- Route:
- intradermal and epicutaneous
- Concentration / amount:
- undiluted
- Details on study design:
- Induction was by intradermal injection of TEG, followed after 7 days by an epicutaneous application.
After a 14 day rest period epicutaneous challenge doses were applied for 24 h and the site inspected for signs of irritation at 24 and 48 h after removal of the challenge patch.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: no data
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- no data
- No. with + reactions:
- 0
- Clinical observations:
- There were no reactions indicating skin sensitization with undiluted TEG.
- Remarks on result:
- other: Reading: other: no data. . Hours after challenge: 24.0. Group: test group. Dose level: no data. No with. + reactions: 0.0. Clinical observations: There were no reactions indicating skin sensitization with undiluted TEG..
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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