Registration Dossier
Registration Dossier
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EC number: 906-256-8 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
- Principles of method if other than guideline:
- LC50 value derived from teratogenicity study
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Details on test material:
- purity nearly 100% throughout the study
Test animals
- Species:
- rat
- Strain:
- other: COBS CD (SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- see 7.8.2 Developmental toxicity / teratogenicity
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- see 7.8.2 Developmental toxicity / teratogenicity
- Duration of exposure:
- 6 h
- Concentrations:
- 0, 150, 1000 or 2500 mg/m3 (0.0, 0.15, 1.00 or 2.5 mg/l = 0, 60, 400 or 1000 ppm)
- No. of animals per sex per dose:
- see 7.8.2 Developmental toxicity / teratogenicity
- Control animals:
- yes
- Details on study design:
- see 7.8.2 Developmental toxicity / teratogenicity
- Statistics:
- see 7.8.2 Developmental toxicity / teratogenicity
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.5 mg/L air
- Exp. duration:
- 6 h
- Mortality:
- see 7.8.2 Developmental toxicity / teratogenicity
- Clinical signs:
- other: see 7.8.2 Developmental toxicity / teratogenicity
- Body weight:
- see 7.8.2 Developmental toxicity / teratogenicity
- Gross pathology:
- see 7.8.2 Developmental toxicity / teratogenicity
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- see 7.8.2 Developmental toxicity / teratogenicity. No evidence of LD50 being reached up to maximum practical aersol concentration, which is also well in excess of the saturated vapour concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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