Registration Dossier
Registration Dossier
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EC number: 206-119-6 | CAS number: 302-23-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hydroxyprogesterone acetate
- EC Number:
- 206-119-6
- EC Name:
- Hydroxyprogesterone acetate
- Cas Number:
- 302-23-8
- Molecular formula:
- C23H32O4
- IUPAC Name:
- (1R,3aS,3bR,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Applicant's summary and conclusion
- Executive summary:
The single oral administration of ZK 5189 to male and female Wistar rats was tolerated without any treatment-related clinical or macroscopic pathological findings. Acute oral toxicity of ZK 5189 in Wistar rats is above 2000 mg/kg body weight. [Schering AG, Report No. X053; 1995-11-27]
Since LD50 > 2000 mg/kg there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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