Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 402-580-4 | CAS number: 111439-76-0 ALKYLSILANE TZ 01748; DYNASYLAN 9405; EURENOR(R) 5020; PSX 5305
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A written assessment of toxicokinetic behaviour is considered appropriate for the substance.
Data source
Materials and methods
- Objective of study:
- other: Assessment of toxicokinetic behaviour
- Principles of method if other than guideline:
- Written assessment based on toxicological profile.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutylisopropyldimethoxysilane
- EC Number:
- 402-580-4
- EC Name:
- Isobutylisopropyldimethoxysilane
- Cas Number:
- 111439-76-0
- Molecular formula:
- Hill formula: C9H22O2Si
- IUPAC Name:
- dimethoxy(2-methylpropyl)(propan-2-yl)silane
- Details on test material:
- Not applicable
Constituent 1
Test animals
- Species:
- other: Not applicable
Administration / exposure
- Details on exposure:
- Not applicable
- Duration and frequency of treatment / exposure:
- Not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not applicable
- No. of animals per sex per dose / concentration:
- Not applicable
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
- Statistics:
- Not applicable
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
In conclusion, there is no evidence that isobutylisopropyldimethoxysilane is significantly absorbed via the dermal route. The results of oral acute and repeated dose toxicity studies with the test substance indicate that it is absorbed orally. Toxic effects were observed in an acute inhalation study indicating absorption by this route. The test substance has been shown to undergo hydrolysis at pH 7 therefore it is possible that the substance undergoes hydrolysis in the gastrointestinal tract probably to (2-methylpropyl)(propan-2-yl)silanediol and methanol. These hydrolysis products are likely to be eliminated rapidly from the body in the urine therefore the test substance is predicted to have a low potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
