Registration Dossier
Registration Dossier
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EC number: 218-644-8 | CAS number: 2210-74-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Following a preliminary screening test a concentration of 50% w/w was selected as the highest dose investigated in the main test.
three groups, each of 4 animals, were treated with 50 ul (25 ul per ear) of the test item as a solution in acetone/olive oil 4:1 at concentrations of 50%, 25% or 10% w/w.
A furhter group of four animals was treated with acetone/olive oil 4:1 alone.
The Stimulation Index expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration 10% w/w in acetone/olive oil 4:1: SI 9.42, Result positive
Concentration 25% w/w in acetone/olive oil 4:1: SI 14.78, Result positive
Concentration 50% w/w in acetone/olive oil 4:1: SI 12.98, Result positive
The test item was considered to be a sensitiser under the conditions of the test.
Migrated from Short description of key information:
The Local Lymph node Assay in the mouse was performed following the OECD Guidelines no. 429 "Skin sensitisation: Local Lymph node Assay" (adopted 22 July 2010) and the Method B.42 Skin Sensitisation (LLNA) of Commission Regulation (EC) no.440/2008.
Justification for selection of skin sensitisation endpoint:
The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: November 2011
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
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