Registration Dossier
Registration Dossier
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EC number: 218-644-8 | CAS number: 2210-74-4
Endpoint summary
Administrative data
Description of key information
The acute dermal irritation/corrosion in the rabbit was performed following the OECD Guidelines no. 404 "Acute Dermal Irritation/Corrosion" (adopted 24 April 2002) and the Method B.4 Acute Toxicity (Skin Irritation) of Commission Regulation (EC) no.440/2008.
The eye irritation in the rabbit was performed following the OECD Guidelines no. 405 "Acute Eye Irritation/Corrosion" (adopted 24 April 2002) and the Method B.5 Acute Toxicity (Eye Irritation) of Commission Regulation (EC) no.440/2008.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation test: The test item produced a primary irritation index of 2.7 and was classified as a moderate irritant to rabbit skin according to the Draize classification scheme.
No corrosive effects were noted.
Eye irritation test:
No corneal or iridial effects were noted during the study.
Minimal conjunctival irritation was noted in all treated eyes one hour after treatment and in 2 treated eyes at the 24 -hr observation.
One treated eye appeared normal at the 24-hr observation and the two other treated eyes appeared normal at the 48 -hr observation.
The test item produced a minimal irritation at 24 -hr observation. No irritation persist at 48 and 72 -hr observations.
Justification for selection of skin irritation / corrosion endpoint:
The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: November 2011
Justification for selection of eye irritation endpoint:
The study was performed in compliance with the principles of the Good Laboratory Practice (GLP).
Experimental data: November 2011
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
In the skin Irritation test, the test item produced a primary irritation index of 2.7 and was classified as a moderate irritant to rabbit skin.
In the eye irritation test, the test item produced a minimal irritation at 24 -hr observation. No irritation persist at 48 and 72 -hr observations.It does not required classification for these hazard.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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