Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other: Modelling database
Principles of method if other than guideline:
Skin sensitisation. Multicase model A33.
GLP compliance:
not specified
Type of study:
other: GPMT or human experience
Species:
other: Guinea pig or human
Strain:
not specified
Sex:
not specified
Route:
other: no data
Vehicle:
no data
Route:
other: no data
Vehicle:
no data
Vehicle:
unchanged (no vehicle)
Reading:
1st reading
Group:
test chemical
No. with + reactions:
0
Clinical observations:
Non sensitising
Remarks on result:
other: Reading: 1st reading. Group: test group. No with. + reactions: 0.0. Clinical observations: Non sensitising.
Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Skin sensitization of bis(pentane-2,4-dionato-O,O')zinc is estimated as negative.
Executive summary:

Skin sensitization of bis(pentane-2,4-dionato-O,O')zinc is estimated as negative.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Skin sensitisation-

Based on the data reviewed of readacross for the sensitisation and considering the weight of evidence approach following was inferred-

Sr. No

End point

effect

Species

Remark

1.

Skin sensitisation

not sensitizing

Guinea pig or human

DEPA RA - 14024-63-6

2.

Skin sensitisation

not sensitizing

Guinea pig or human

DEPA RA- 3264-82-2

Both the read across values for the target, bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, indicate that the substance do not have sensitising effect on skin and so based on the weight of evidence of these read across substances it can be inferred that the target substanceas well will be non sensitising to skin.

Migrated from Short description of key information:

Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium is non sensiting to skin based ont eh weight of evidence of two read across values.

Justification for selection of skin sensitisation endpoint:

Both the read across values for the target, bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, indicate that the substance do not have sensitising effect on skin and so based on the weight of evidence of these read across substances it can be inferred that the target substanceas well will be non sensitising to skin.

Justification for classification or non-classification

Bis (pentane-2,4-dionato-O,O')bis(propan-2-olato) titanium is non sensiting to skin based on the weight of evidence of two read across values.