Registration Dossier
Registration Dossier
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EC number: 413-010-9 | CAS number: 6613-44-1 DMBC
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 July 1992 - 4 February 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Method A7
- Deviations:
- yes
- Remarks:
- Test A7 is designed for determination of absolute values of fat solubility. Since DMBC was found to have infinite solubility in Standard Fat, a modified test procedure was used.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,5-dimethylbenzoyl chloride
- EC Number:
- 413-010-9
- EC Name:
- 3,5-dimethylbenzoyl chloride
- Cas Number:
- 6613-44-1
- Molecular formula:
- C9H9ClO
- IUPAC Name:
- 3,5-dimethylbenzoyl chloride
- Details on test material:
- Name: DMBC
Appearance: clear, colourless liquid
Storage conditions: room temperature in the dark
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- standard fat
- Temp.:
- 37 °C
- Remarks on result:
- other: Miscible in all propertions
- Test substance stable:
- yes
- Details on results:
- All the prepared mixtures were observed to form a homogeneous phase.
Any other information on results incl. tables
Table 1 Analytical Data
Mass of Standard Fat (g) |
Mass of DMBC (g) |
% DMBC (w/w) |
Observation |
0.94644 0.89973 0.79999 0,69988 0.59430 0.50083 0.39305 0,30510 0.19689 0.10042 0.05020 |
0.06187 0.10970 0.20769 0.29506 0.43059 0.49489 0.63009 0.70013 0.80494 0.89859 0.94838 |
6.1 10.9 20.6 29.7 42.0 49.7 61.6 69.6 80.3 89.9 95.0 |
Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase Homogeneous phase |
Applicant's summary and conclusion
- Conclusions:
- DMBC has been found to be miscible in all proportions with Standard Fat HB 307 at 37 °C.
- Executive summary:
DMBC has been found to be miscible in all proportions with Standard Fat HB 307 at 37 °C. The test was conducted in accordance with EEC Method A7.
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