Registration Dossier
Registration Dossier
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EC number: 236-537-4 | CAS number: 13423-15-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The toxicokinetics of tetrahydro-3-methylfuran (3-methyl-THF) have not been derived experimentally but, based on read-across to tetrahydrofuran (THF, CAS # 109-99-9), is expected to be readily absorbed into the blood stream following oral exposure where it will be rapidly metabolized, and ultimately excreted primarily, via the respiratory route, as carbon dioxide. In addition, 3-methyl-THF, may be slowly absorbed through the skin.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The toxicokinetics of tetrahydro-3-methylfuran (3-methyl-THF) have not been derived experimentally. However, as an alternative to testing, the information on absorption, distribution, metabolism, and excretion of tetrahydrofuran (THF, CAS # 109-99-9) has been used to assist in predicting 3-methyl-THF’s toxicokinetic properties. Chemical and physical properties, available toxicological data, in combination with known biochemical processes will also be utilized to be able to read-across from THF to 3-methyl-THF.
3-methyl-THF is expected to be readily absorbed into the blood stream following oral exposure, has the potential to be absorbed through the skin, and is expected to be rapidly metabolized, by a mixed-function oxidase, to 3-methyl gamma-butyrolactone then to 2-methyl gamma-hydroxybuturic acid and then to a 2-methyl succinic semialdehyde and then to 2-methyl succinic acid, in a scheme nearly identical to THF (see Justification for Read Across). In THF metabolism, succinic acid can be converted to products that can enter the (TCA) citric acid cycle (Fenner-Crisp, 2011) and be ultimately excreted primarily, via the respiratory route, as carbon dioxide (see lead registrant's dossier for THF).
Using U.S. EPA DERMWIN v2.01, the dermal absorption rate of 3-methyl-THF is estimated to be 0.0595 mg/cm2/hr with a permeability coefficient of 0.00409 cm/hr. No measured data for dermal absorption were available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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