Registration Dossier
Registration Dossier
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EC number: 261-819-9 | CAS number: 59587-44-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across
Key value for chemical safety assessment
Additional information
Data on the short-term toxicity of 2-ethylhexanol nonanoate (CAS
59587-44-9) to aquatic organisms are not available. The assessment was
therefore based on studies conducted with the structurally most similar
substance Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2) was
conducted to fulfill the data requirement. The short-term toxicity of
Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2) as part of a
read across approach, which is in accordance with Regulation (EC) No.
1907/2006, Annex XI, 1.5. Further justification is given within the
overall summary chapter 6.1 and within the analogue justification.
The short-term toxicity of Fatty acids, C8-16, 2-ethylhexyl esters (CAS
135800-37-2) to aquatic invertebrates was investigated in a limit test
according to EU Method C.2 under GLP conditions (Wierich, 1998). Daphnia
magna were exposed to the substance under static conditions for 48
hours. A water accommodated fraction (WAF) of 100 mg/L (nominal) was
tested. Undissolved test substance was removed by filtration. No
immobilisation was observed in the treatment throughout the test period
of 48 h. Hence, the 48 h-EC50 is determined to be > 100 mg/L based on
the nominal test concentration. Thus, the substance is not expected to
by acutely toxic to aquatic invertebrates up to the limit of water
solubility.
Thus, based on the above mentioned result, and due to the structural and
profile similarities of the substances, as are explained with in the
overall endpoint summary 6.1 it can be concluded that no toxicological
effects on aquatic invertebrates are expected up to the limit of water
solubility for 2-ethylhexanol nonanoate (CAS 59587-44-9).
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