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EC number: 260-330-8 | CAS number: 56677-60-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound tetradecyl chloroformate: With high probability acutely not harmful to fish.
Hydrlysis product tetradecanol: Not harmful to fish (no mortality at maximum water solubility).
Hydrolysis product HCL: Acutely toxic for fish (pH-dependent).
Key value for chemical safety assessment
Additional information
Parent compound tetradecyl chloroformate:
The toxicity of the parent compound tetradecyl chloroformate (CAS 56677 -60 -2) to fish was tested according to OECD 203 (Fish, Acute Toxicity Test) with the species Danio rerio. The determined 96 -h LC50 value was > 1000 < 2150 mg/L (BASF AG, 1988, 17F0618/965174). The test substance is poorly water soluble. Therefore, all test solutions were milky cloudy and showed fat like droplets on the watersurface as increasing with the concentrations.
Dissolved tetradecyl chloroformate hydrolyses rapidly to the nearly unsoluble tetradecanol (CAS 112 -72 -1), HCL (CAS 7647 -01 -0) and CO2 (CAS 124 -38 -9). Therefore, the results as presented below, indicate that both the parent compound and its main hydrolysis product are not harmful to fish up to their maximum water solubility.
Tetradecanol:
Read across was made to the hydrolysis product tetradecanol. An acute toxicity test was performed according to OECD 203 (Fish, Acute Toxicity Test) with the test organism Oncorhynchus mykiss. The obtained LC50 (96 -h) was > 1 mg/L (SafePharm Laboratories, 1996, project no.: 140/559).
As reported in the SIAR for Long Chain Alcohols (OECD, 2006), the toxicity of the single carbon number chain length alcohols increases from an LC50 of 97 mg/L for C6 to 1.0 mg/L for C12. At higher carbon numbers there is an absence of acute toxicity (LC50 values are reported as being greater than the highest test concentration) and this is explained by the water solubility of an alcohol limiting its bioavailability, such that an acutely toxic concentration is not achieved.
Hydrolysis product hydrochloric acid (HCl):
HCl was tested in a semi-static acute toxicity test according to OECD 203 with Cyprinus carpio. The 96-h LC50 was 4.92 mg/L (acid equivalent to pH 4.3; OECD, 2002).
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