Dichloro(chloromethyl)methylsilane

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: DOT Guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: DOT

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dichloro(chloromethyl)methylsilane

EC Number:

216-319-5

EC Name:

Dichloro(chloromethyl)methylsilane

Cas Number:

1558-33-4

Molecular formula:

C2H5Cl3Si

IUPAC Name:

dichloro(chloromethyl)methylsilane

Details on test material:

Purity 98 %

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

The rabbits were assigned animal numbers using a computerized randomization process. This proc-ess involved generating random numbers, assigning the random numbers to the animals, and rank-ing the random numbers. Using this randomly ranked list, six male rabbits were assigned to this study. The rabbits were identified uniquely by individual ear tags and housed individually in elevated metal cages. Commercial rabbit ration (Purfna Lab Rabbit Chow ,5321) and tap water were available at libitum except where noted otherwise. The rabbits were acclimated to laboratory conditions for a minimum of one week prior to initiation of treatment. Rabbits were used in this study because they have historically been used in safety evaluation studies and are required by appropriate regulatory agencies.

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

not specified

Controls:

no

Amount / concentration applied:

0,5 ml

Duration of treatment / exposure:

4 hr

Observation period:

none

Number of animals:

6 males

Details on study design:

Prior to treatment, the dorsal area of each rabbit was clipped free of hair. and one site was chosen for application. A 0.5 ml aliquot of the test material was introduced onto each intact site under a one by one inch square gauze patch (two layers thick) which was secured in place with transparent tape. The trunk of each rabbit was wrapped with impervious rubber damming. The rabbits were then im-mobilized in stocks for four hours without food and water. Four hours following application, the bind-ers and patches were removed, and the exposure sites were washed with water to preclude further exposure of the animal to the test material. The test material was administered dermally because potential human exposure is by the dermal route.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

edema score

Basis:

mean

Time point:

24/48/72 h

Score:

> 4

Max. score:

4

Reversibility:

not reversible

Remarks:

Corrosive

Results 2

Irritation parameter:

erythema score

Basis:

mean

Time point:

24/48/72 h

Score:

> 4

Max. score:

4

Reversibility:

not reversible

Remarks:

Corrosive

Results 3

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 4 h

Reversibility:

not reversible

Remarks on result:

other: substance was corrosive to the skin

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

The substance is corrosive to the skin

Executive summary:

The test material chloromethyl-methyl-dichlorosilane. was evaluated for skin corrosivity potential in rabbits following a single dermal application. Extreme blanching and blackened tissue was observed in all rabbits at four hours post application. No edema or other dermal effects were noted. Due to the skin destruction,. the animals were sacrificed four hours after application of test material.