Registration Dossier
Registration Dossier
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EC number: 211-765-7 | CAS number: 693-98-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- BASF test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylimidazole
- EC Number:
- 211-765-7
- EC Name:
- 2-methylimidazole
- Cas Number:
- 693-98-1
- Molecular formula:
- C4H6N2
- IUPAC Name:
- 2-methyl-1H-imidazole
- Details on test material:
- - Name of test material (as cited in study report): 2-Methylimidazol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 200, 250, 320, 400, 800 and 1600 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 24 and 48 hours and day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 350 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 and 250 mg/kg group: none of the animals died
320 mg/kg group: 1/10 animals died
400 mg/kg group: 9/10 animals died
800 and 1600 mg/kg group: all/10 animals died - Clinical signs:
- Junmping cramps, morphed tails, dyspnoea and lying on the stomach
- Body weight:
- Normal body weight gain
- Gross pathology:
- Substance remaining in and agglutination of the abdominal cavity
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
