Benzylamine

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: acceptable publication

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Hippuric acid excretion after benzylamine ingestion in man

Author:

Wood SG et al.

Year:

1978

Bibliographic source:

British Medical Association, Tavistock Square, London WC1H9JR

Reference 2

Reference Type:

publication

Title:

Benzylamine metabolism

Author:

Wood SG et al.

Year:

1978

Bibliographic source:

The chemical environment- Fd Cosmet. Toxicol. Vol 17, no.5

Materials and methods

Objective of study:

excretion

Principles of method if other than guideline:

The fate of 14C-benzylamine after oral administration as the hydrochloride has been investigated in two human male volunteers.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Benzylamine

EC Number:

202-854-1

EC Name:

Benzylamine

Cas Number:

100-46-9

Molecular formula:

C7H9N

IUPAC Name:

1-phenylmethanamine

Details on test material:

Radiolabelled benzylamine in the form of (methylene-14C) benzylamine hydrochloride (specific activity 56 nCi/mmol). The total radioactivity was diluted with distilled water to give a final solution containing 1.00 µCi/mL. Unlabelled benzylamine hydrochloride was prepared by the dropwise addition of concentrated hydrochloric acid to a stirred solution of benzylamine in ether.

Radiolabelling:

yes

Test animals

Species:

human

Sex:

male

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

other: Each 14C-benzylamine hydrochloride dose was prepared by dissolving unlabelled benzylamine hydrochloride (100 mg) in 20 mL (10 µCi) aqueous 14C-benzylamine.

Duration and frequency of treatment / exposure:

single administration

Doses / concentrations

Remarks:

Doses / Concentrations:
Each 14C-benzylamine hydrochloride dose was prepared by dissolving unlabelled benzylamine hydrochloride (100 mg) in 20 mL (10 µCi) aqueous 14C-benzylamine.

Results and discussion

Any other information on results incl. tables

The fate of 14C-benzylamine after oral administration as the hydrochloride has been investigated in two male volunteers. Over 98% of the administered radiolabel was excreted in the urine as 14C-hippuric acid within 24 hours. The rate of urinary hippuric acid excretion was extremely rapid, with more than 90% of the dose excreted after three hours.

Urinary excretion of radioactivity following an oral dose of 14C-benzylamine hydrochloride

Subject	Time (hr)	Total urine volume (ml)	radioactivity excreted per time interval (%dose)	Cumulative radioactivity excreted (% dose)
A	0.5	20	66.55	66.55
	1	16	17.62	84.17
	2	64	9.55	93.72
	3	45	2.42	96.14
	4	34	1.14	97.28
	5	25	0.49	97.77
	6	25	0.37	98.14
	7	25	0.23	98.37
	8	24	0.18	98.55
	10	50	0.20	98.75
	12	105	0.16	98.91
	24	630	0.29	99.20
B	0.25	50	3.02	3.02
	0.50	83	25.26	28.28
	1	92	37.84	66.12
	2	122	20.07	86.19
	3	130	4.56	90.75
	4	112	2.37	93.12
	5	90	1.29	94.42
	6	57	0.86	95.28
	7	39	0.57	95.85
	8	28	0.38	96.23
	9	36	0.33	96.56
	10	47	0.29	96.85
	12	120	0.35	97.20
	24	940	0.93	98.13