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EC number: 250-938-1
CAS number: 32162-27-9
a primary dermal irritation study performed according to OECD Guideline
404 and in compliance with GLP, three New Zealand albino rabbits were
dermally exposed to 0.5 mL of undiluted EPOXY ALPHA PINENE GAUCHE under
a semi-occlusive patch for 4 h on clipped skin. After removal of the
dressings, irritation was scored as outlined in the OECD Guideline 404
at 1, 24, 48 and 72 h after exposure.
The application of the test item produced
one hour after patch removal, in all animals, the outbreak of well
defined erythema with slight to moderate edema. During the first 72
hours, erythematous reactions were maintained or decreased in the
rabbits and the oedematous reactions decreased in all the rabbits. The
reversibility of this cutaneous reactions was complete within 8 days for
one rabbit and 9 days for the 2 others.
scores over 24, 48 and 72 h for each animal were 2.0, 1.3 and 2.0 for
erythema and 2.3, 1.3 and 2.3 for edema.
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