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EC number: 250-938-1
CAS number: 32162-27-9
The mutagenic potential of alpha pinene
epoxide (unspecified isomer) has been assessed in a good-quality Ames
test similar to that described by OECD Guideline 471.
In two independent tests (using the plate
incorporation method), triplicate cultures of Salmonella typhimurium strains
TA 98, TA 100, TA 1535 and TA 1537 were incubated with alpha pinene
epoxide (in DMSO) at 0, 0.1, 0.3, 1.0, 3.3 or 10.0 μmole/plate [about
15, 45, 150, 500 or 1520 μg/plate], in the absence or presence of
metabolic activation with rat liver S9. Appropriate positive controls
were also tested. The number of revertant colonies was then determined.
No convincing evidence of mutagenic activity
was seen for alpha piene epoxide (unspecified isomer). Although there
appeared to be a slight treatment-related increase in the number of
revertant Salmonella TA 100 colonies without S9, this was less than
double the controls. Significant cytotoxicity was seen in cultures
treated with the highest concentration.
Based on these study findings, and according
to the EU CLP and DSD regulations, there is no requirement to classify
this substance as mutagenic.
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