Registration Dossier
Registration Dossier
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EC number: 239-816-9 | CAS number: 15721-78-5
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
Using Bio-concentration Factor (v12.1.0.50374) module the Bio-concentration Factor of the test chemical was estimated to be >1000000 dimensionless at pH range 3-14. This value indicates that the chemical is bioaccumulative in aquatic organisms as this value exceeds 2000 criteria of CLP regulation.
Additional information
Bioaccumulation: aquatic/sediments:
Various studies have been reviewed for test chemical and its read across chemical for Bioaccumulation endpoint and their results are summarized below.
In first study Using Bio-concentration Factor (v12.1.0.50374) module the Bio-concentration Factor of the test chemical was estimated to be >1000000 dimensionless at pH range 3-14.
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance was estimated to be 6140 dimensionless . The predicted BCF result was based on the 5 OECD principles
Last study was reviewed from authoritative database (HSDB) in this study the BCF value of test chemical estimated was 6000 dimensionless by using log Kow of 5.28 and regression derived equation and it is more than 2000 criteria of CLP regulation. On the basis of calculated BCF value it is concluded that chemical is bioaccumulative in aquatic organisms.
By considering results of all the studies mentioned above the BCF value of test chemical can be in range 6140-1000000. This range BCF value indicates that the test chemical is very bioaccumulative in nature.
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