Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-816-9 | CAS number: 15721-78-5
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental results of test chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as- 2. and 3.
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Transformation products:
- not specified
- pH:
- 7
- DT50:
- 13 yr
- Type:
- second order
- Remarks on result:
- other: 2. Based catalyzed second order hydrolysis rate constant is 0.016 L/mol-sec .
- pH:
- 8
- DT50:
- 1.3 yr
- Type:
- second order
- Remarks on result:
- other: 2.Based catalyzed second order hydrolysis rate constant is 0.016 L/mol-sec .
- Type:
- not specified
- Remarks on result:
- other: 3. test chemical is not hydrolysable
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, the half life of hydrolysis of test chemical can be estimated to be 13 years at pH 7 pH on the basis of this value it can be concluded that the test chemical is not hydrolysable.
- Executive summary:
Two studies have been reviewed to determine the hydrolysis reaction of the test chemical. The studies are as mentioned below:
The first study was reviewed from authoritative database (HSDB) in this the half-life and base catalyzed hydrolysis rate constant of the test chemical was estimated using structure estimation method. The based catalyzed hydrolysis rate constant of test chemical was determined to be 0.016 L/mol-sec, respectively with a corresponding half-lives of 13 and 1.3 years at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.
Another study was reviewed fom authoritative database (HSDB) in this study it is mentioned that the test chemical is resistant to aqueous environmental hydrolysis , i.e., test chemical is not hydrolyasble.
On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, the half life of hydrolysis of test chemical can be estimated to be 13 years at pH 7 pH on the basis of this value it can be concluded that the test chemical is not hydrolysable.
Reference
Description of key information
On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, the half life of hydrolysis of test chemical can be estimated to be 13 years at pH 7 pH on the basis of this value it can be concluded that the test chemical is not hydrolysable.
Key value for chemical safety assessment
Additional information
Two studies have been reviewed to determine the hydrolysis reaction of the test chemical. The studies are as mentioned below:
The first study was reviewed from authoritative database (HSDB) in this the half-life and base catalyzed hydrolysis rate constant of the test chemical was estimated using structure estimation method. The based catalyzed hydrolysis rate constant of test chemical was determined to be 0.016 L/mol-sec, respectively with a corresponding half-lives of 13 and 1.3 years at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.
Another study was reviewed fom authoritative database (HSDB) in this study it is mentioned that the test chemical is resistant to aqueous environmental hydrolysis , i.e., test chemical is not hydrolyasble.
On the basis of the results of both the studies mentioned above and applying the weight of evidence approach, the half life of hydrolysis of test chemical can be estimated to be 13 years at pH 7 pH on the basis of this value it can be concluded that the test chemical is not hydrolysable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
