Registration Dossier
Registration Dossier
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EC number: 443-870-0 | CAS number: 163520-33-0
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
PBT/vPvB criteria and justification
Evidence of non-P / non-vP properties
The substance is quickly eliminated from both water body and sediment, with hydrolysis to the free acid and further biodegradation of this hydrolysis product (DT50 0.19 and 1.5 days (0.4 and 3.2 days at 12 °C) based on data obtained from soil and water/soil systems from Europe and the U-S.). Anaerobic degradation is also fast (DT50 of 0.6 d (1.3 d at 12 °C) in water/sediment system and 0.02 d (0.042 d at 12 °C) in soil).
Conclusion on P / vP properties: not P/vP
Evidence of non-B / non-vB properties
-Not B / vB based on Log Kow <= 4.5: The test substance will be hydrolysed fast in the relevant pH range and Log Pow values of the hydrolysis products are far below 3. For this hydrolysis products, there exists a determination of the log Pow over a pH range from 4-10 thus showing that the log Pow is very low (-2.38 to - 0.18). For higher pH, the log Pow can also be assumed to be negative due to salt formation. Quantitative structure-activity relationship analysis resulted in a calculated BCF of 24 - 177 L/kg (VEGA 1.1.5; Meylan Model v1.0.3/CAESAR v2.1.14/Arnot-Gobas v1.1.5).
Conclusion on B / vB properties: not B/vB
Evidence of T properties
The substance is classified as Xn, R48 according to Directive 67/548/EEC and for specific target organ toxicity after repeated exposure (STOT RE 2; H373) according to Regulation EC No 1272/2008 due to the renal effects observed in dogs after subacute, subchronic and chronic exposure, in mice after subacute exposure and in rats after subchronic exposure (two-generation reproductive toxicity study). Thus, the substance fulfils the toxicity criterion (T).
Conclusion on T properties: T
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