Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 701-402-5 | CAS number: -
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1971
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modified Draize test
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- EC Number:
- 243-528-9
- EC Name:
- Dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Cas Number:
- 20120-33-6
- Molecular formula:
- C6H14NO5P
- IUPAC Name:
- dimethyl [3-[(hydroxymethyl)amino]-3-oxopropyl]phosphonate
- Reference substance name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- EC Number:
- 219-765-9
- EC Name:
- Dimethyl (3-amino-3-oxopropyl)phosphonate
- Cas Number:
- 2526-69-4
- Molecular formula:
- C5H12NO4P
- IUPAC Name:
- dimethyl (3-amino-3-oxopropyl)phosphonate
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 103
- Sex: not specified
- Age: not specified
- Race: not specified
- Demographic information: not specified - Clinical history:
- Not specified
- Route of administration:
- dermal
- Details on study design:
- This is a modified Draize test. The fabric samples were used as provided. The test patch was a Johnson & Johnson occlusive non-perforated Band Aid. They were applied to the same site on the back for 48 hours during the week and 72 hours on the weekend for a total of 10 such applications. This was
followed by a rest period, final elicitation and retests as indicated at fresh site.
Results and discussion
- Results of examinations:
- There were no positive responses in the final elicitation. There were no dropouts except for administrative purposes or lack of volunteer cooperation.
Applicant's summary and conclusion
- Conclusions:
- No allergic contact dermatitis was seen.
- Executive summary:
Purpose: To determine the contact sensitization potential of treated fabric samples Pyrovatex CP and Aerotex Resin 23 Special.
Method: This is a modified Draize test. The test patch was a Johnson & Johnson occlusive nonperforated band aid. They were applied to the same site on the back for 48 hours during the week and 72 hours on the weekend for a total of 10 such applications. This was followed by a rest period, final elicitation and retests as indicated at fresh site.
Results: There were no positive responses in the final elicitation. There were no dropouts except for administrative purposes or lack of volunteer cooperation.
Conclusion: In the 103 subjects in this modified Draize test with fabric samples there was no evidence of allergic contact dermatitis.
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