Methyl L-threoninate

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-03-19 to 2013-11-06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Principles of method if other than guideline:

NA

GLP compliance:

yes (incl. QA statement)

Type of method:

method according to Siwoloboff

Test material

Test material information

Constituent 1

Reference substance name:

Methyl L-threoninate

EC Number:

222-158-1

EC Name:

Methyl L-threoninate

Cas Number:

3373-59-9

Molecular formula:

C5H11NO3

IUPAC Name:

Methyl (2S,3R)-2-amino-3-hydroxy-butanoate

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): L-threonine methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.8%
- Lot/batch No.: X5UYC99
- Expiration date of the lot/batch: July 2014
- Storage condition of test material: Frozen

Results and discussion

Boiling point

Key result

Atm. press.:

1 023 mBar

Decomposition:

yes

Decomp. temp.:

> 124 °C

Remarks on result:

other: No boiling was noted.

Any other information on results incl. tables

The results of the definitive boiling point determinations on L-TME were as follows:

Barometric pressure: 1023 mbar.

As the tubes were heated at 1˚C/minute, samples were observed to cloud, initially at the meniscus at approximately 124°C, and then throughout the whole body of the sample at 128˚C. No boiling was noted. The observations were indicative of decomposition of the sample.

Applicant's summary and conclusion

Conclusions:

The boiling temperature of L-TME was not determinable, as the test substance decomposed at temperatures above approximately 124°C without boiling.

Executive summary:

The boiling temperature of L-TME was measued in accordance to OECD 103. The boiling temperature was not determinable, as the L-TME decomposed at temperatures above approximately 124°C without boiling.