Methyl L-threoninate

Oxidising properties

Administrative data

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-03-19 to 2013-11-06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

no guideline followed

Guideline:

other: Based on the chemical structure of L-TME the oxidising properties were predicted to be negative.

Principles of method if other than guideline:

It is possible to predict the oxidising potential of a molecule by analogy with existing compounds and therefore it is possible to examine the chemical structure of a substance and ascertain whether or not there are any groups present that are associated with oxidising properties. For this purpose a screening procedure has been published in Appendix 6 of the United Nations ‘Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria’.

For organic compounds, the substance does not possess oxidising properties if it does not contain oxygen, fluorine or chlorine. If these atoms are present, then the substance does not possess oxidising properties if the atoms are chemically bonded only to carbon and hydrogen.

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Methyl L-threoninate

EC Number:

222-158-1

EC Name:

Methyl L-threoninate

Cas Number:

3373-59-9

Molecular formula:

C5H11NO3

IUPAC Name:

Methyl (2S,3R)-2-amino-3-hydroxy-butanoate

Test material form:

other: Evaluation performed based on the chemical structure of L-TME

Details on test material:

- Name of test material (as cited in study report): L-threonine methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.8%

Results and discussion

Test results (Oxidising solids)

Key result

Sample tested:

other: Examination of chemcial structure

Parameter:

other: Examination of chemcial structure

Remarks on result:

other: Examination of chemcial structure

Any other information on results incl. tables

From an examination of the chemical structure of L-TME, it was confirmed that it contained oxygen, but only chemically bonded to carbon and hydrogen. Consequently, L-TME is not expected to possess oxidising properties.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

From the assessment of the chemical structure it is established that L-TME does not have oxidising properties.

Executive summary:

From the examination of the chemical structure of L-TME, it was confirmed that it contained oxygen, but only chemically bonded to carbon and hydrogen. Consequently, from the assessment of the chemical structure it is established that L-TME does not have oxidising properties.