N-L-alanyl-L-tyrosine

Boiling point

Administrative data

Endpoint:

boiling point

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is a solid which decomposes before boiling

the study does not need to be conducted because chemical change occurred during the melting point study

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

- Principle of test: determination of melting point
- Short description of test conditions: determination in the context of de novo synthesis at laboratory scale
- Parameters analysed / observed: melting point

GLP compliance:

no

Type of method:

other: not specified

Key result

Melting / freezing pt.:

>= 238 - <= 241 °C

Atm. press.:

1 003 hPa

Decomposition:

yes

Decomp. temp.:

>= 238 °C

Sublimation:

no

Remarks on result:

other: melting with decomposition

A constant melting point was not available. The substance foamed at 155 - 167 °C and lost water. It became solid again at 180 °C. Sintering took place at 230 °C. At 238 - 241 °C, melting with decomposition was observed.

Conclusions:

The substance was reported to melt with decomposition at 238 - 241 °C.