Registration Dossier
Registration Dossier
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EC number: 221-305-7 | CAS number: 3061-88-9
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 Mar - 25 May 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: VDI Guideline 2263, Part 1
- Version / remarks:
- 1990
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- Version / remarks:
- 2019
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Key result
- Test procedure:
- other: Grewer Oven
- Max. temp. reached:
- 340
- Result:
- negative outcome (no effect observed)
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- The pure test item L-Alanyl-L-Tyrosine Dihydrate indicated no self-ignition at atmospheric pressure.
On the basis of the results of the tests on the self-ignition in the Grewer Oven the test item is classified as follows:
UN Transport Regulation: The test item is not classified as self-heating substance in Class 4, Division 4.2 according to the UN Transport Regulation.
GHS / CLP Regulation (EC) No 1272/2008 Annex I: 2.11: The test item is not classified as self-heating substance according to GHS/CLP Regulation (EC) No 1272/2008 Annex I: 2.11. - Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Principles of method if other than guideline:
- - Principle of test: Flammability of solids (Lütolf method)
- GLP compliance:
- no
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was reported to show brief ignition and quick extinction (BZ = 2) in a flammability study according to Lütolf.
Referenceopen allclose all
Bewertungszahl BZ = 2 (brief ignition; quick extinction)
Description of key information
not flammable (Lütolf method)
not self-heating (Grewer oven, GLP)
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
The substance was reported to show brief ignition and quick extinction (BZ = 2) in a flammability study according to Lütolf.
The pure test item L-Alanyl-L-Tyrosine Dihydrate indicated no self-ignition at atmospheric pressure.
Justification for classification or non-classification
The available data indicate that the substance does not fulfil the classification criteria for flammability in accordance with Regulation (EC) No. 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labelling (GHS).
On the basis of the results of the tests on the self-ignition in the Grewer Oven the test item is classified as follows:
UN Transport Regulation: The test item is not classified as self-heating substance in Class 4, Division 4.2 according to the UN Transport Regulation.
GHS / CLP Regulation (EC) No 1272/2008 Annex I: 2.11: The test item is not classified as self-heating substance according to GHS/CLP Regulation (EC) No 1272/2008 Annex I: 2.11.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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