Reaction product of salicylaldehyde and formaldehyde and phenol

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 October 2018 to 12 October 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

capillary method

Key result

Melting / freezing pt.:

>= 62.1 - <= 70.2 °C

Atm. press.:

>= 98.5 - <= 98.9 kPa

Decomposition:

no

Using a linear heating rate of 0.5°C/minute, the melting range of the test material was found to be 62.1 - 70.2°C ± 0.16°C (95 % confidence interval), i.e. 335.2 – 343.3 K. The details are summarised below.

 

Measured temperatures corresponding to the melting of the test material (three experiments (I, II, III) with three parallel samples each (1, 2, 3)).

	Measured Temperatures during the main Study (°C)
	I / 1	I / 2	I / 3	II / 1	II / 2	II / 3	III / 1	III / 2	III / 3	Mean
Beginning of melting	61.9	61.9	61.9	61.8	61.9	61.9	62.4	62.4	62.4	62.1 ± 0.20
Final stage of melting	69.9	69.9	69.9	70.2	70.2	70.3	70.3	70.4	70.4	70.2 ± 0.16

 

No significant change of colour or other changes suggesting degradation were observed until the melting of test material.

Conclusions:

Under the conditions of the study the melting point of the test material was determined to be 62.1 - 70.2°C.

Executive summary:

The melting point of the test material was assessed in accordance with the standardised guidelines OECD 102 and EU Method A.1 under GLP conditions.

For the determination of the melting point or melting range, the capillary method using a metal block was applied. A small amount of the test material was placed in a capillary tube and packed tightly, then heated in the electronic controlled sample block and the temperature around the sample was displayed. The sample was observed visually while raising the temperature at an appropriate rate in an appropriate range. The initial and final melting temperatures were determined.

Using a linear heating rate of 0.5°C/minute the melting range of the test material was found to be 62.1 - 70.2°C ± 0.16°C (95 % confidence interval), i.e. 335.2 – 343.3 K. No significant change of colour or other changes suggesting degradation were observed until the melting of test material.

Under the conditions of the study the melting point of the test material was therefore determined to be 62.1 - 70.2°C.

Description of key information

Under the conditions of the study the melting point of the test material was determined to be 62.1 - 70.2°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

62.1 °C

Additional information

The melting point of the test material was assessed in accordance with the standardised guidelines OECD 102 and EU Method A.1 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

For the determination of the melting point or melting range, the capillary method using a metal block was applied. A small amount of the test material was placed in a capillary tube and packed tightly, then heated in the electronic controlled sample block and the temperature around the sample was displayed. The sample was observed visually while raising the temperature at an appropriate rate in an appropriate range. The initial and final melting temperatures were determined.

Using a linear heating rate of 0.5°C/minute the melting range of the test material was found to be 62.1 - 70.2°C ± 0.16°C (95 % confidence interval), i.e. 335.2 - 343.3 K. No significant change of colour or other changes suggesting degradation were observed until the melting of test material.

Under the conditions of the study the melting point of the test material was therefore determined to be 62.1 - 70.2°C.