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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

study results are available for oral and inhalative route. No study on dermal route available.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
before 2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study is written japaneses
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Specific details on test material used for the study:
not specified
Species:
mouse
Strain:
not specified
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
1200 mg/kg, 1560 mg/kg, 2028 mg/kg, 2636.4 mg/kg, 3427.3 mg/kg, 4455.5 mg/kg and 5792.2 mg/kg
No. of animals per sex per dose:
10 animals per sex per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 10 days
- Frequency of observations and weighing: each day
- Necropsy of survivors performed: unknown
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 028 mg/kg bw
Based on:
test mat.
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 2 900 mg/kg bw
Based on:
test mat.
Mortality:
observed and documented (day 0 till day 10)
Interpretation of results:
GHS criteria not met
Conclusions:
The LD 50(mouse) for male and female do not lead to a classification according to GHS.
Executive summary:

The study was preformed equivalent or similar to the OECD 401 (acute oral toxicity). The results LD 50(mouse) for male 2028 mg/kg bw and for female 2900 mg/kg bw can be regarded as reliable.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 028 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating conc.
Value:
3 200 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

For the oral route, the available information is conclusive but not sufficient for classification as acute toxic.

For the inhalative route, the available information is conclusive but not sufficient for classification as acute toxic.

No experimental information is available on toxicity by dermal route. Based on information on toxicity by oral and inhalative route, skin irritation and skin sensitisation, no hazard can be identified. Therefore it is concluded, that no classification applies.