Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-244-6 | CAS number: 3040-44-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The substance is acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer:
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 2-piperidinoethanol (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on the acute toxicity to aquatic invertebrates are not provided.
Assessment:
No experimental data on the acute toxicity of 2-piperidinoethanol are available. In Annex VII section 9.1.1, column 2 of Regulation (EC) No 1907/2006, it is laid down that a short-term toxicity study on aquatic invertebrates does not need to be conducted if a long-term aquatic toxicity study on invertebrates is available.
A long-term toxicity study on Daphnia magna is available for the Substance (BASF SE, 2020; Project No.: 51E0154/18E038).
However, the short-term toxicity of 2-piperidinoethanol (CAS 3040-44-6) to aquatic invertebrates was estimated using the QSAR Toolbox v.4.4. The toxicity of the target chemical (48-h LC50 = 78.5 mg/L) is predicted from category members using the arithmetic mean of six nearest neighbours (range 12.8 - 711 mg/L). The target chemical falls within the applicability domain of the prediction.
2-Piperidinoethanol is acutely harmful to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
