Registration Dossier
Registration Dossier
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EC number: 221-244-6 | CAS number: 3040-44-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful for fish
Key value for chemical safety assessment
Additional information
A non-GLP study was conducted with 2-piperidinoethanol in accordance with DIN 38 412 (1982) to determine the potential toxicity of the test substance. In this static study Leuciscus idus was used as test species.
The study was performed using not-pH-adjusted test solutions (10 to 100 mg/L). The highest test solution was also tested after pH-adjustment as the substance induces a pH shift to alkaline conditions.
Mortality was only observed in the highest treatment (100 mg/L) without pH-adjustment probably due to the high pH (pH 9.7), while no fish died in the lower treatments and the highest treatment of 100 mg/L with pH adjustment (BASF AG 1988, report no. 10F0587/875275).
The concentrations were not analytically verified. However, the test concentrations are assumed to be stable over the exposure period based on a sufficient water solubility, a low Henry's Law constant (1.85E-04 Pa*m³/mol, est., see IUCLID Ch. 5.4.2) and a low adsorption potential (log Kow = -0.62, meas., see IUCLID Ch.4.7; log Koc = 2.4, meas., see IUCLID Ch. 5.4.1). In addition, a growth inhibition study on algae concluding analytical measurements was performed with 2-piperidinoethanol (BASF SE, 2019; study no. 60E0154/18X059). This test demonstrated that the substance was stable over the exposure period of 72 hours (see IUCLID Ch. 6.1.5).
In conclusion, based on the available experimental data it can be concluded that 2-piperidinoethanol (CAS 3040-44-6) is with high probability acutely not harmful for fish.
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