Registration Dossier
Registration Dossier
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EC number: 274-092-8 | CAS number: 69709-01-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In vitro Bacterial reverse mutation assay (Ames test): the substance, 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, was negative with and without metabolic activation in S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102 (Eurofins, 2016). The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Additional information from genetic toxicity in vitro:
1,1,3,3 -Tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine has been tested in a valid bacterial mutation assay, conducted according to OECD TG 471, and in compliance with GLP, using S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102. No increase in the number of revertants was observed in any of the five test strains, with and without metabolic activation, when tested up to cytotoxic concentration. Appropriate solvent, negative and positive controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
1,1,3,3-Tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine contains no structural elements which may be of concern for potential mutagenic activity. In vitro tests bacterial mutagenicity study result is negative.
Justification for classification or non-classification
Based on the available data for 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, no classification is required for genetic toxicity according to Regulation (EC) No. 1272/2008.
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