Registration Dossier
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EC number: 274-092-8 | CAS number: 69709-01-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A 48 hour EC50 value of >122 mg/l (geometric mean) (highest concentration tested) has been determined for the effects of the hydrolytic degradation product of the test item 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, on mobility of Daphnia magna.
Key value for chemical safety assessment
Additional information
A 48 hour EC50 value of >122 mg/l (measured, geometric mean) (highest concentration tested) has been determined for the effects of the hydrolysis product of the test item 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, on mobility of Daphnia magna, in accordance with OECD guideline 202. No effects were observed during the test and there were no differences in effects between the pH adjusted and unadjusted test solutions.
Since the pH of the test item concentration 100 mg/L was considered to be outside the recommended range of pH 6 – 9, the concentration level 100 mg/L was tested pH-adjusted (pH 8.2 ± 0.5) and un-adjusted to distinguish toxic effects of the test item from pH effects.
In view of the test media preparation method and exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. The study was supported by LC-MS/MS analysis of the silanol hydrolysis product in fresh and aged media. The measured concentrations of the hydrolysis product in fresh and aged media were in the range of 106 to 151% of the nominal values.
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