Registration Dossier
Registration Dossier
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EC number: 208-964-6 | CAS number: 549-18-8
Endpoint summary
Administrative data
Description of key information
Aquatic acute toxicity
Daphnia magna, water Flea, 48 h, EC50 = 4.82 mg/L
Spirostomum ambiguum (Protozoa), 48 h, EC50 = 0.41 mg/L
Fish, Danio rerio (Zebra Danio), 96 h, LC50 = 1.9 mg/L
Above data are selected from ECOTOX database of EPA.
LC50 (Sheepshead minnow, 4 days): 0.37 mg/l (this data has been taken by the SDS of the substance elaborated by EUROPEAN DIRECTORATE FOR THE QUALITY OF MEDICINES & HEALTHCARE, EDQM).
Spirotox is a short-term acute toxicity test with a large ciliated protozoan Spirostomum ambiguum. Spirotox was found to be very sensitive to heavy metals, fungicides, and pharmaceuticals used to cure diseases of the human nervous system. On the other hand, it was generally less sensitive than standard bioassays to simple organics (source: Nałecz-Jawecki G, Spirotox-Spirostomum ambiguum acute toxicity test-10 years of experience, Environ Toxicol. 2004).
Aquatic chronic toxicity
Adequate Chronic toxicity data are not available. In ECOTOX database of EPA one value of NOEC of 0.1 mg/L for fish (Danio rerio, Zebra Danio) is reported. This NOEC has been determined after 120 hr of exposure and the effect is mortality.
The following acute toxcicity data has been used for the classification of the substance for chronic hazards.
Daphnia magna, water Flea, 48 h, EC50 = 4.82 mg/L
Spirostomum ambiguum (Protozoa), 48 h, EC50 = 0.41 mg/L
Fish, Danio rerio (Zebra Danio), 96 h, LC50 = 1.9 mg/L
Above data are selected from ECOTOX database of EPA.
LC50 (Sheepshead minnow, 4 days): 0.37 mg/l (this data has been taken by the SDS of the substance elaborated by EUROPEAN DIRECTORATE FOR THE QUALITY OF MEDICINES & HEALTHCARE, EDQM)
Spirotox is a short-term acute toxicity test with a large ciliated protozoan Spirostomum ambiguum. Spirotox was found to be very sensitive to heavy metals, fungicides, and pharmaceuticals used to cure diseases of the human nervous system. On the other hand, it was generally less sensitive than standard bioassays to simple organics.
The logKow od the substance is 4.92.
Overall, the substance is classified as Aquatic Chronic 1.
Additional information
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