Registration Dossier
Registration Dossier
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EC number: 266-411-4 | CAS number: 66576-71-4
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Literature review
- Study period:
- 1998 - 1999
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Objective of study:
- absorption
- metabolism
- Qualifier:
- no guideline required
- Radiolabelling:
- no
- Species:
- other: none
- Route of administration:
- oral: feed
- Type:
- absorption
- Results:
- Short branched chain carboxylic acids and their esters are rapidly absorbed from the gastrointestinal tract.
- Type:
- metabolism
- Results:
- Hydrolysis of Isopropyl Methyl-2-Butyrate would be catalysed by esterases occurs in the gastrointestinal tract, skin, blood or liver forming ethanol and a carboxylic acid.
Reference
Description of key information
Absorption
Short branched chain carboxylic acids and their esters are rapidly absorbed from the gastrointestinal tract.
Metabolism
Hydrolysis of Isopropyl Methyl-2-Butyrate would be catalysed by esterases occurs in the gastrointestinal tract, skin, blood or liver forming ethanol and a carboxylic acid.
The free carboxylic acid undergoes β-oxidation; this reaction involves initial esterification with the thiol group of coenzyme A (CoA) followed by
oxidation and finally cleavage forming acetyl-CoA and propionyl-CoA. The oxidation products are all endogenous compounds and enter the tricarboxylic acid cycle (TCA), ultimately being eliminated as carbon dioxide.
References
Safety evaluation of certain food additives and contaminants. WHO Food Additives Series, No. 40, 1998.
Evaluation of certain food additives and contaminants. WHO Technical Report Series, No. 884, 1999.
The following information is taken into account for any hazard / risk assessment:
IMB will be rapidly absorbed from the GI tract, metabolised to endogenous compounds, ultimately being eliminated as carbon dioxide.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
