Registration Dossier
Registration Dossier
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EC number: 236-610-0 | CAS number: 13450-90-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
According to the umu test with or without metabolic activation (S9 mix), the test item Gallium trichloride is not mutagenic.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
- Version / remarks:
- umu test
- GLP compliance:
- not specified
- Type of assay:
- SOS/umu assay
- Specific details on test material used for the study:
- purity > 99.9%
- Species / strain / cell type:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 mix: a mixture of the microsome fraction of a rat liver with coenzymes such as reduced nicotinamide adenine dinucleotide phosphate and reduced nicotinamide adenine dinucleotide, was used
- Test concentrations with justification for top dose:
- at least 6 concentrations, ranging from 7.2 × 10−7 to 1.4 × 10−4 mol/L
- Vehicle / solvent:
- In advance of mutagenic evaluation, each of the salts was dissolved in and diluted with sterile Dulbecco’s phosphate- buffered saline without calcium and magnesium salts [PBS(−)] to prepare a proper metal salt solution, which would provide a desired final concentration of the salt in the medium.
- Untreated negative controls:
- yes
- Remarks:
- PBS
- Positive controls:
- yes
- Positive control substance:
- furylfuramide
- other: 2-aminoanthracene
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Conclusions:
- The test item Gallium trichloride is not mutagenic, with or without metabolic activation (S9 mix).
- Executive summary:
The test item Gallium trichloride is not mutagenic, with or without metabolic activation (S9 mix).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the umu test with or without metabolic activation (S9 mix), the test item Gallium trichloride is not mutagenic.
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