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Diss Factsheets
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EC number: 276-115-7 | CAS number: 71873-39-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- in vivo
- Type of information:
- other: read across form similar substance (analogue structure or surrogate)
- Adequacy of study:
- key study
- Study period:
- From April 01st to May 08th, 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- adopted July 17, 1992
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Already available study
Test material
- Reference substance name:
- Similar Substance 03, AR336
- IUPAC Name:
- Similar Substance 03, AR336
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Pirbright-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann, D-33178 Borchen. SPF breeding colony.
- Weight at study initiation: mean 388 g.
- Housing: in fully air-conditioned rooms in macrolon cages (type 4) on soft wood granulate in groups of 5 animals.
- Diet: ssniff® Ms-H (V2233), ad libitum.
- Water: tap water in plastic bottles, ad libitum.
- Acclimation period: at least 7 days.
ENVIRONMENTAL CONDITIONS
- Temperature: 20 ± 3 °C
- Relative humidit: 50 ± 20 %
- Photoperiod: 12 hours daily dark / 12 hrs light.
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 20.0 % in deionized water
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- none
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- none
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- positive control
- Dose level:
- 20 % alpha-hexyl cinnamic aldehyde in polyethylene glycol 400
- No. with + reactions:
- 6
- Total no. in group:
- 20
- Remarks on result:
- positive indication of skin sensitisation
Any other information on results incl. tables
Irritations during the sensitization phase
Discrete or patchy erythema occurred sporadically in the treatment group after the first induction treatment. Discrete or patchy up to moderate and confluent erythema were observed in the treatment group during the sensitization phase after the second and third administration. The animals of the control group showed no signs of irritation during the sensitization phase.
Based on these results, a 20 % preparation of test item in deionized water was selected for the challenge treatment.
Dermal challenge treatment
No signs of irritation were observed in the control and the treatment group 24 and 48 hours after removal of the occlusive bandage.
Body weight gains and clinical signs
The body weight gains of the animals were not impaired. The treated animals showed no clinical signs of intoxication throughout the study. 0
RANGE FINDING TESTS
No signs of irritation occurred after administration of the different test concentrations.
Based on these results, 100 % test item was selected for the sensitization treatments.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified, according to the CLP Regulation (EC) No 1272/2008
- Conclusions:
- Not skin sensitising
- Executive summary:
Testing for the sensitizing properties of test item was performed in female guinea pigs according to the method of Burhelr, according to the OECD guideline 406.
Dermal induction was performed using 100 % test item moistened with deionized water. The control group was exposed to deionized water only. Challenge treatment was carried out with 20 % test item in deionized water. The validity of the test system is confirmed by the periodically conducted positive control test using alpha-hexyl cinnamic aldehyde for the Buehler test.
No signs of irritation were observed in the control and the treatment group 24 and 48 hours after removal of the occlusive bandage. Based on the results of the study, the substance showed no evidence for sensitizing properties.
Conclusion
Not skin sensitising
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