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EC number: 203-430-9 | CAS number: 106-75-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis product diethylene glycol: readily biodegradable, but failing 10-d window
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
As oxidiethylene bischloroformate (DIBIS, CAS 106-75-2) rapidly hydrolyses in contact with water (see IUCLID Ch. 5.1.2), the analysis of the parent compound is of low relevance. Biodegradation does not apply to the inorganic hydrolysis products (HCl and CO2); therefore, only the biodegradation of diethylene glycol (DEG, CAS 111-46-6) is assessed here.
Several results on the ready biodegradability of the hydrolysis product diethylene glycol are available: see table below. According to the available study reports, the substance fulfils the ready biodegradability criteria within the 28-d test period; however, the 10-day window criterion is failed in all of the available studies.
DEG can be assessed as „biodegradable“ or „readily biodegradable, but failing the 10-d window“. The substance is not readily biodegradable according to the OECD criteria.
The inherent biodegradability of DEG is supported by a OECD 302C study (NITE, 2017).
This assessment is in agreement with the substance evaluation report within CoRAP (ECHA, 2016), which also came to the conclusion that DEG is biodegradable.
According to the OECD SIDS Dossier for Diethyleneglycol (OECD, 2004), DEG is moderately biodegradable.
Test method |
Result |
Remarks |
Reference |
OECD 301A (DOC Die-Away Test) |
101% in 28 d (DOC) readily biodegradable, but failing 10-d window |
GLP; reliability: 1; weight of evidence |
BASF AG (1994); report no. 94/1175/21/1 |
OECD 301A (DOC Die-Away Test) |
102% in 28 d (DOC) readily biodegradable, but failing 10-d window |
GLP; reliability: 1; weight of evidence |
BASF AG (1995); report no. 94/1175/21/2 |
OECD 301B (CO2 Evolution Test) |
71% in 28 d (CO2) 99% in 28 d (DOC) readily biodegradable, but failing 10-d window |
non-GLP; reliability: 2; weight of evidence |
BASF AG (1995); report no. 94/1129/22/1 |
Standard biodegradation tests |
Moderately biodegradable |
reliability: 2; weight of evidence |
OECD (2004) |
OECD 302C (MITI-(II)-Test) |
90% in 28 d (BOD) 88% in 28 d (TOC) 90% in 28 d (test material, GC) Inherently biodegradable |
reliability: 2; weight of evidence |
NITE (2017) |
[Type of water: freshwater]
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