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EC number: 915-640-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The eye irritation test included instillation of an aliquot of 0.1 g of the test material into each conjunctival sac of a male New.Zealand White rabbit. The right eye was washed for two minutes with tap water after a 30-second exposure. The left eye was not washed immediately after exposure. At various time intervals both eyes were examined for conjunctival irritation, corneal injury and irritation of the iris.
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]
- EC Number:
- 915-640-4
- Molecular formula:
- C22 H30 O7 S2 . 2 Na
- IUPAC Name:
- Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]
- Details on test material:
- Chemical Name : XU-40340.00. DOWFAX 3B2, Powder Form
Appearance: tan solid
Source: Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Male New Zealand White rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5g
- Duration of treatment / exposure:
- Washed eye- 30 second exposure
Unwashed eye - Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- The eyes of the rabbit were established as being without defects or irritation 24 hours prior to study initiation. The eye irritation test included instillation of an aliquot of 0.1 g of the test material into each conjunctival sac of a male New Zealand White rabbit. The right eye was washed for two minutes with tap water after a 30-second exposure. The left eye was not washed immediately after exposure. At various time intervals both eyes were examined for conjunctival irritation, corneal injury and irritation of the iris. The eyes were anesthetized if moderate pain eas observed or anticipated. A drop of 5% aqueous fluorescein stain was used to aid in assessing corneal injury.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48, and 72 h and 7, 14 and 21 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48 and 72 h and 7 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed and after stain
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 14 and 21 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed and after stain
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24 and 48 h
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 72 h, 7, 14 and 21 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- not washed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24, 48, and 72 h and 7 and 14 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 21 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48, and 72 h and 7 days
- Score:
- 4
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed and after stain
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 14 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed and after stain
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 21 days
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed and after stain
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 h and 7 days
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 14 and 21 days
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: eye- washed
- Irritant / corrosive response data:
- The eye irritation test included instillation of an aliquot of 0.1 g of the test material into each conjunctival sac of a male New.Zealand White rabbit. The single exposure resulted in moderate discomfort, moderate conjunctival redness and swelling, moderate reddening of the iris, and moderate corneal injury. Ocular effects were still present in both eyes at day 21 of the test and included slight to moderate conjunctival irritation, slight corneal injury, and slight reddening of the iris. Ophthalmic anesthetic was administered to alleviate discomfort experienced by the rabbit.
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Not reversible
- Conclusions:
- A single exposure of New Zealand White rabbit eyes to the test material resulted in moderate discomfort, moderate conjunctival redness and swelling , moderate reddening of the iris, and moderate corneal injury. Ocular effects were still present in both eyes at day 21 of the test and included slight to moderate conjunctival irritation, slight corneal injury, and slight reddening of the iris. Ophthalmic anesthetic was administered to alleviate discomfort experienced by the rabbit.
- Executive summary:
The test material, XU-40340.00 DOWFAX 3B2 powder form, was submitted by the Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company, Midland, MI. The material is of interest for use in the agriculture, cleaning, and textile industries. Standard acute toxicologic tests were conducted and included the acute oral toxicity, skin irritation, and eye irritation studies.
A single exposure of New Zealand White rabbit eyes to the test material resulted in moderate discomfort, moderate conjunctival redness and swelling , moderate reddening of the iris, and moderate corneal injury. Ocular effects were still present in both eyes at day 21 of the test and included slight to moderate conjunctival irritation, slight corneal injury, and slight reddening of the iris. Ophthalmic anesthetic was administered to alleviate discomfort experienced by the rabbit.
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