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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Three female Fischer 344 rats received the test material, as a 20% aqueous solution, by single dose oral gavage, at dose levels of 1500 or 2000 mg/kg.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]
EC Number:
915-640-4
Molecular formula:
C22 H30 O7 S2 . 2 Na
IUPAC Name:
Reaction mass of Disodium decyl(sulphonatophenoxy)benzenesulphonate and Disodium oxybis[decylbenzenesulphonate]
Details on test material:
Chemical Name : XU-40340.00. DOWFAX 3B2, Powder Form
Appearance: tan solid
Source: Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
female
Details on test animals or test system and environmental conditions:
No additional data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
Rats received the test material, as a 20% aqueous solution, by single dose oral gavage.
Doses:
1500 and 2000 mg/kg
No. of animals per sex per dose:
3 females/dose
Control animals:
no
Details on study design:
Three female Fischer 344 rats received the test material, as a 20% aqueous solution, by single dose oral gavage, at dose levels of 1500 or 2000 mg/kg. In-life observations and body weights were recorded over a 2-week observation period.
Statistics:
None

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 1 500 - < 2 000 mg/kg bw
Mortality:
No rats died at 1500 mg/kg and 2 out of 3 died at 2000 mg/kg.
Clinical signs:
other: In-life signs of toxicity observed on both dose groups included diarrhea. Lethargy, palpebral closure, and facial soiling (reddish color) were observed in the high dose animals only.
Gross pathology:
No data
Other findings:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Conclusions:
The acute oral LD50 for female rats was between 1500 and 2000 mg/kg.
Executive summary:

The test material, XU-40340.00 DOWFAX 3B2, powder form, was submitted by the Specialty Chemicals Technical Services & Development Department, The Dow Chemical Company, Midland, MI. The material is of interest for use in the agriculture, cleaning, and textile industries. Standard acute toxicologic tests were conducted and included the acute oral toxicity, skin irritation, and eye irritation studies. The acute, oral LD50 for female Fischer 344 rats was between 1500 and 2000 mg/kg. Therefore, the acute oral toxicity of the test material was categorized as low.