Registration Dossier
Registration Dossier
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EC number: 225-303-7 | CAS number: 4763-79-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-[2-[4-(2-benzoxazoleyl)phenyl]vinyl]benzoic acid
- EC Number:
- 225-303-7
- EC Name:
- 4-[2-[4-(2-benzoxazoleyl)phenyl]vinyl]benzoic acid
- Cas Number:
- 4763-79-5
- Molecular formula:
- C22H15NO3
- IUPAC Name:
- 4-[2-[4-(2-benzoxazoleyl)phenyl]vinyl]benzoic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- sample no. 0808024164
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- water
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No abnormal findings after 24/46/72 hours (Erythema;Oedema,Flaking,Staining)
light yellow staining produced by the test item after 1 h
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- is considered to be "not irritating" to rabbit skin.
- Executive summary:
The primary skin irritation potential of BENZoXAZoLSTILBENoARBoNSAEURE was
investigated by topical semi-occlusive application of 0.5 g to the intact left flank of each of
three young adult New Zealand White rabbits. The duration of treatment was four hours. The
scoring of skin reactions was performed 1, 24, 48 and 72 hours after removal of the
dressing.
The test item did not elicit any skin reactions at the application site of any animal at any of
the observation times (all scores 0). The individual mean score for erythema/eschar and
oedema for each of the three animals was therefore 0. A light yellow staining was however
observed at the test site of all animals but only at the 1-hour examination. No corrosive
effects were noted on the treated skin of any animal at any of the measuring intervals.
Thus, the test item did not induce significant or irreversible damage to the skin.
Based upon the referred classification criteria (Commission Directive 20O1l59lEC of
August06, 2001), BENZOXAZOLSTILBENCARBONSAEURE is considered to be "not
irritating" to rabbit skin.
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