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EC number: -
CAS number: -
a 6 or 7-day oral gavage study, plasma steady state concentration
appeared to have been reached by day 4 for both male and female rats.
There was evidence that the test substance preferentially partitioned
into the liver in both male and female rats. A second toxicokinetic
study in male and female rats via single oral gavage or i.v. injection
revealed that the terminal elimination half-life ranged from 28-38 hours
in males and 21-38 hours in females. Bioavailability
of the test substance decreased as the dose increased indicating
saturation in absorption. The
test substance did not accumulate in females, but did accumulate to a
small degree in male rats following 14-day repeated oral gavage.
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