Registration Dossier
Registration Dossier
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EC number: 209-812-1 | CAS number: 593-84-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Refer to justification attached below - Reason / purpose for cross-reference:
- read-across source
- Preliminary study:
- In none of the buffer solutions at pH 4, 7 and 9 at 50 °C more than 10 % of the test substance hydrolysed within 5 days.
- Transformation products:
- no
- Key result
- pH:
- 4.06
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 6.97
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 8.77
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- On the basis of the pre-test results and in accordance with the guidances no main test has been performed.
- Conclusions:
- Available data from Guanidinium carbonate were used to evaluate the hydrolytic stability of Guanidinium thiocyanate.
The hydrolytic stability of Guanidine carbonate (CAS 593-85-1) was invetigated in a study according to the OECD TG 111 protocol.
The GLP-study is considered reliable and conclusive for chemical safety assessment and classification purposes.
The pre-test indicated a half-life at 25 °C of more than one year.
Thus no DT50 was determined and the guanidine kation is considered hydrolytically stable under environmental conditions.
Reference
Description of key information
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
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