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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according EU/OECD guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
N1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-methylphenyl]-N2-(1-methanesulfinyl-2-methylpropan-2-yl)benzene-1,2-dicarboxamide
EC Number:
609-338-9
Cas Number:
371771-07-2
Molecular formula:
C23H23F7N2O3S
IUPAC Name:
N1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-methylphenyl]-N2-(1-methanesulfinyl-2-methylpropan-2-yl)benzene-1,2-dicarboxamide

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: tap water with 2% Cremophor EL
Doses:
300 and 2000 mg/kg bw
No. of animals per sex per dose:
3 female rats
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
500 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

According to OECD guideline 423 the LD50 cut-off of the test substance is 500 mg/kg bw. (Category 4 of the Globally Harmonized Classification System).

A dose of 300 mg/kg body weight was tolerated by female rats without mortalities, clinical signs, effects on weight gain and gross pathological findings.

All animals dosed with 2000 mg/kg body weight died during the observation period. The clinical signs were decreased motility, uncoordinated gait, spasmodic state, narrowed palpebral fissure and inclined head posture in one animal.

The gross pathology investigations revealed:

lung, discoloration, pale and spotted;

liver, discoloration, pale and spotted;

spleen, discoloration, pale.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU