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EC number: 306-522-8 | CAS number: 97281-23-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxic effects to aquatic invertebrates up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of fatty acids, C16-18, 2-hydroxyethyl ester, (CAS 97281-23-7) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to structurally related substances (CAS 85116-97-8 and 68583-51-7) was conducted.
The study with the read-across substance fatty acids C16-C18 ester with diethylene glycol (CAS 85116-97-8) was performed according to the OECD guideline 202 under GLP compliance (Ladwa, 2015). The water flea Daphnia magna (< 24 h old) was exposed to a nominal loading of 100 mg/L which was prepared as Water Accommodated Fraction to remove any undissolved test material. The actual exposure concentrations were verified by HPLC/MS analysis. 0.0642 mg/L and 0.0255 mg/L were analysed after 0 h and 48 h, respectively. After exposure of 48 h no immobile daphnids were observed resulting in an EL50 (48 h) > 100 mg/L (nominal).
A further read across study investigating the short-term toxicity of decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) to aquatic invertebrates is available (Scholz, 1995). The study was performed according to EU Method C.2 (GLP) with Daphnia magna in a static exposure regime. The test species were exposed to a Water Accommodated Fraction (WAF) of 1000 mg/L (nominal) for 48 h. A DOC analysis of the WAF resulted in a test substance concentration of 2.4 mg/L (measured, geom. mean). No effects were observed after 48 h. Thus, an EL50 of > 1000 mg/L (WAF) or 2.4 mg/L (measured, geom. mean) was determined.
Based on the results from the above described structurally related read across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be considered that the fatty acids, C16-18, 2-hydroxyethyl esters (CAS 97281-23-7) will not exhibit short term effects to aquatic invertebrates up to the limit of water solubility.
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