Styrene

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Contact allergy to styrene with cross reaction to vinyltoluene

Author:

Sjöborg, S. et al.

Year:

1982

Bibliographic source:

Contact Dermatitis 8: 207-208

Reference 2

Reference Type:

review article or handbook

Title:

European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.

Author:

European Union

Year:

2007

Bibliographic source:

Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007

Materials and methods

Type of sensitisation studied:

skin

Study type:

other: contact and patch tests with single person

Principles of method if other than guideline:

Contact allergy to styrene was tested in a 40-year-old man by the Patch test.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Styrene

EC Number:

202-851-5

EC Name:

Styrene

Cas Number:

100-42-5

Molecular formula:

C8H8

IUPAC Name:

ethenylbenzene

Specific details on test material used for the study:

- Name of test material (as cited in study report): Styrene
- Analytical purity: no data

Method

Type of population:

other: private and occupational

Ethical approval:

not applicable

Subjects:

- Number of subjects exposed: 1
- Sex: male
- Age: 40

Clinical history:

- History of allergy or casuistics for study subject or populations:
A 40-year-old man had asthmatic bronchitis as a child and has always had dry skin, but no atopic dermatitis. For 20 years, his work has involved repairing and maufacturing machines in a food factory. At times the skin on his fingertips has been dry and fissured. Owing to this condition he was referred to the clinic. 2 years ago after repairing his own car with plastic padding he developed acute vesicular hand dermatitis.

Controls:

no data

Route of administration:

dermal

Details on study design:

TYPE OF TEST(S) USED: patch test (epicutaneous test)

Tests with Styrene:
first test: Styrene (5% v/v in MEK)
second test: Styrene (0.1% v/v in MEK)
third test: patch test with Styrene, at least with 2 concentrations: 0.001% w/v and 0.0001% w/v
fourth test: Styrene (0.01%)

Parallel several tests were done with other components of the plastic padding and inhibitors of styrene polymerisation

Results and discussion

Results of examinations:

Patch testing with an internationally agreed series and with polymerisation inhibitors which are added to styrene gave negative reactions. However, there was a positive reaction with styrene itself.