Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-802-9 | CAS number: 12034-34-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
Disodium titanate has been tested in one in vivo skin sensitisation study (Local lymph node assay (LLNA) in mice). This study shows a negative response, thus disodium titanate does not require classification as sensitiser.
Justification for classification or non-classification
Sensitisation
The reference Vogel (2010) is considered as the key studies on skin sensitisation and will be used for classification. The sensitisation results are as follows:
SIs of less than 3.0 were observed at all test concentrations of disodium titanate (5, 10, 25%). Therefore, the EC3 value could not be
calculated, since none of the tested concentrations induced an SI greater than 3.
Thus, the classification criteria acc. to regulation (EC) 1272/2008 as skin sensitizer are not met since 0% of the test animals responded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
