Registration Dossier
Registration Dossier
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EC number: 234-802-9 | CAS number: 12034-34-3
Endpoint summary
Administrative data
Description of key information
Disodium titanate has been tested in one in vitro skin irritation and one in vitro skin corrosion study as well as in one in vitro eye irritation study. All tests show a negative response, thus disodium titanate does not require classification either as skin or as eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
Skin irritation
The test method based on the EPISKIN™ assay allows the prediction of both irritant and non-irritant substances and can thus be considered as a stand alone method to be used as replacement for the animal test. After treatment with the test item Disodium titanate the relative absorbance values were decreased to 93.8%. This value is well above the threshold for irritancy of <= 50%. Therefore, the test item is not considered to possess an irritant potential. Disodium titanate is considered not to have skin irritating properties and should not be classified and labelled according to regulation (EC) No.: 1272/2008.
Skin corrosion
The test method based on the Corrositex™ assay allows the discrimination between corrosive and non-corrosive chemical substances and mixtures. After treatment of the bio-barriers with Disodium titanate for more than 60 minutes the colour of the CDS reagent did not change. Therefore, Disodium titanate is considered as non-corrosive and should not be classified and labelled according to regulation (EC) No.: 1272/2008.
Eye irritation
Disodium titanate is not considered to be an eye irritant and should not be classified and labelled according to regulation (EC) No.: 1272/2008.
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