Registration Dossier
Registration Dossier
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EC number: 203-698-7 | CAS number: 109-72-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
n-Butyl lithium is pyrophoric and would react violently upon contact with water or air humidity, releasing flammable butane and corrosive lithium hydroxide, and likely starting a fire. Thus, an AMES test (Bacterial Reverse Mutation Assay) or other in vitro mutagenicity tests with n-Butyl lithium as such are technically not feasible. For classification, the results of two in vitro tests (AMES test, chromosome aberration test) with Lithium hydroxide anhydrous were considered.
Both, the AMES test and the chromosome aberrations test with Lithium hydroxide anhydrous did not reveal any evidence for mutangenicity. Thus, it can be concluded that also n-Butyl lithium is not mutagenic in such tests as it would react violently on exposure to animal tissues, releasing lithium hydroxide and butane and also butane is not known to be mutagenic.
No classification and labelling for genotoxicity is required according to Regulation (EC) No 1272/2008 (CLP) or Directive 67/548/EC (DSD) criteria.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available data, n-Butyl lithium is not classified for genotoxicity according to Regulation (EC) No 1272/2008 (CLP) or Directive 67/548/EC (DSD) criteria.
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