Registration Dossier
Registration Dossier
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EC number: 205-550-7 | CAS number: 142-62-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available. In the publication less than basic data is given.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- THE PLACE OF THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY
- Author:
- Smyth, H. F. Jr. and Carpenter, C. P.
- Year:
- 1 944
- Bibliographic source:
- Journal of Industrial Hygiene and Toxicology 26:269 - 273
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were given a single dose by gavage of different concentrations of hexanoic acid until two dosages differing by a multiple of ten are identified with one concentration killing some or all animals and the other one killing no or some animals. Then the LD50 value was estimated graphically.
- GLP compliance:
- no
- Test type:
- other: "range-finding" oral toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- Hexanoic acid
- EC Number:
- 205-550-7
- EC Name:
- Hexanoic acid
- Cas Number:
- 142-62-1
- Molecular formula:
- C6H12O2
- IUPAC Name:
- hexanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight rats: 90 - 120 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- The applied doses differed by a multiple of ten; not further specified.
- No. of animals per sex per dose:
- 6 males per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: estimated value
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
