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EC number: 205-550-7 | CAS number: 142-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 03 September - 06 September 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- The concentration of the substance during test was not maintained within ± 20% of the nominal concentration. Neverthelss, the result of the test was analysed with nominal concentration.
- GLP compliance:
- yes
- Remarks:
- according to Japanese GLP standard
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: -10/-7 °C
- Boiling point: 223 °C
- Vapour pressure: 1 mmHg at 78 °C, 10 mmHg at 113.2 °C, 100 mmHg at 160 °C
- Water solubility (under test conditions): 2410 mg/L at 15 °C - Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: 2 mL of test water was directly sampled by each vessel before study initiation. After exposure, test water was sampled and centrifuged to remove algae (3000 rpm, 10 min).
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Test item was dissoved in dilution water. The concentration of stock solution was 100 mg/L. Each concentration was prepared by diluting stock solution.
- Controls: Blank control
- Evidence of undissolved material (e.g. precipitate, surface film, etc): Apperance of test water was clear colorless in all concetration. - Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Algae
- Strain: ATCC22662
- Source (laboratory, culture collection): American Type Culture Collection
- Age of inoculum (at test initiation): Within 4 days
- Method of cultivation:
ACCLIMATION
- Acclimation period: 2002-08-30 to 2002-09-03
- Culturing media and conditions (same as test or not): same as test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Test temperature:
- 23.5 - 24.2 °C
- pH:
- 5.7 - 9.8
- Nominal and measured concentrations:
- Nominal concentration: control, 10, 15, 22, 32, 46, 68 and 100 mg/L
Measured concentration: (0 hour and 72 hours): - ; 10.7 and 7.9; 14.7 and 13.5; 21.1 and 19.2; 31.0 and 27.5; 48.4 and 39.9; 70.4 and 62.6; 108 and 86.6 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 300 mL Erlenmeyer flask
- Type: Capped with air-permeable stopper
- Material, fill volume: Glass, 100 mL
- Initial cells density: 10000 cells/mL
- Control end cells density: 2436100 ± 597200 cells/mL
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
GROWTH MEDIUM
- Standard medium used: yes
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: no
- Photoperiod: continuously
- Light intensity and quality: 4000 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: electronic particle counter;
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.5
- Range finding study: Performed twice
- Test concentrations: (1) 1, 10 and 100 mg/L, (2) 5 and 10 mg/L
- Results used to determine the conditions for the definitive study:
(1) Growth rate after 72 hours was 100% in control group, 87% in 1 mg/L group, 88% in 10 mg/L group and 0% in 100 mg/L group.
(2) Growth rate after 72 hours was 100 %in control group, 85% in 5 mg/L group and 91% in 10 mg/L group. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 52.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 56.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 36.9 - 86.4 mg/L
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test): No abnormality was observed - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50: 0.473 mg/L - Reported statistics and error estimates:
- The NOEC were determined by an analysis of variance (ANOVA), Dunnett test, subsequent to Bartlett test for homogeneity of variances. Statistical analyses were performed using Yukms Statlight # 4 software.
Reference
Table 1. Percent growth inhibition
Nominal Concentration (mg/L) |
Biomass |
Growth rate (24-72 h) |
Inhibition (%) *1 |
Inhibition (%) *1 |
|
Control |
- |
- |
10 |
- 17.2 |
- 3.7 |
15 |
- 23.6 + |
- 2.7 |
22 |
- 29.4 ++ |
- 1.2 |
32 |
-30.3 ++ |
- 2.3 |
46 |
27.6 * |
11.6 ** |
68 |
95.9 +++ |
87.2 ** |
100 |
99.8 +++ |
99.7 ** |
*1 Values are the percent inhibition relative to the control.
* Indicates a significant difference (α = 0.05) from the control.
** Indicates a significant difference (α = 0.01) from the control.
+++ Statistical comparison test could not be performed for this concentration. However, it was concluded that this concentration level showed adverse effect on Algal growth.
+, ++ This concentration level showed a significant difference (+: α= 0.05, ++: α = 0.01), but it was concluded that this concentration level did not show adverse effect on Algal growth.
Description of key information
ErC50 (72 h, growth rate) = 56.4 mg/L (nominal, OECD 201)
NOErC (72 h, growth rate) = 32 mg/L (nominal, OECD 201)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 56.4 mg/L
- EC10 or NOEC for freshwater algae:
- 32 mg/L
Additional information
No data on toxicity to algae are available for hexanoic acid C6 (CAS 142-62-1).
Therefore ecotoxicological effects are predicted from adequate and reliable data for a source substance by read-across to the target substance within the group applying the group concept in accordance with Annex XI, Item 1.5, of Regulation (EC) No 1907/2006.
Due to an increasing toxicity with increasing chain length from hexanoic acid C6 to decanoic acid C10 for aquatic organisms read across is performed to heptanoic acid C7 (CAS 111-14-8) since this substance is the most structurally related one in comparison to hexanoic acid.
In the study provided from the Ministry of the Environment, Government of Japan (2002), heptanoic acid C7 was tested according to OECD 201 under GLP-conditions. Selenastrum capricornutum was exposed to 0, 10, 15, 22, 32, 46, 68 and 100 mg/L (nominal, measured values in the range of 80 - 120% of nominal concentrations). The ECr50 (72 h) and NOErC were stated as 56.4 mg/L and 32 mg/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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